SCD Lifestyle is essentially a business that creates profit by educating individuals about gut health. It makes sense to do such a thing, as the individuals who run the business have put a lot of effort and research into dealing with their gut issues, so they might as well profit right? Actually, I don’t think the answer to that question is so straightforward.
Nevertheless, I have written transcripts for a few of their videos. When I first watched the videos I found them pretty overwhelming and so I attempted to make sense of the information presented through writing. Hopefully someone will find this useful, and may even come up with ideas regarding what might be causing their gut issues. Remember, you can find your own answers.
Here is the third list of transcripts. It is worth noting these are only partial videos, as SCD Lifestyle sell the full videos alongside full transcripts. Despite this, I have found the partial videos very useful as they have put into perspective just how important it is that I fix my gut issues to avoid further physical degeneration. It has also opened up a new realms of knowledge to explore, of particular interest to me, given my previously difficult existence is the concept of adrenal fatigue. I see now that it is also possible that I might be in danger of acquiring an autoimmune disease assuming that I don’t already have one.
The Exact Process of How Autoimmune Disease Starts:
Autoimmunity and autoimmune disease are separated by the quantity of damage and the symptoms it produces. Symptoms are caused when enough damage to tissues happens. The point at which autoimmunity leads to autoimmune disease varies from person to person, depending on the tissue being attacked, and the aggressiveness of the autoimmune disease. Symptoms can include more benign things such as fatigue, headaches, muscle pain, mood issues, skin conditions including rashes, dry skin and acne.
Two things have to happen to create an autoimmune disease, that is to move from a state of generalized inflammation, to a targeted attack on the part of the adaptive immune system. . The first thing is the production of a antibody, a protein. There are cells in the adaptive immune system that produce antibodies, which target specific entities, which are usually foreign invaders. Antibodies have a structure that resembles a Y. The of tips of the Y, have antigen binding sites on them, this is like a lock and therefore it acts to acquire the appropriate key. It is looking for a specific sequence of around 15-20 amino acids, as it does not recognise whole proteins, which it binds to. It follows that the antibody is looking for a specific protein fragment. In doing this the antibody signals to the adaptive and innate immune system that there is something that needs attacking. There are millions of antibodies in our immune system. Every cell produces a type of antibody which bonds a specific protein fragment.
When the cells of the innate immune system find something they tell production cells to produce antibodies specific to the invader. Other parts of the immune system decide whether the production of these antibodies is a good idea or not.
What can happen is that because antibodies are binding to very small protein fragments, they can bind to sites that are not specific to a forgein invader. This happens because there are structural similarities in cells and these similarities are necessary for life. Unfortunately this means that antibodies may attack the body.
There are certain things that make the autoimmune response more likely, including genetics, and infections. Some infections are more likely to lead to the production of antibodies that also recognise the body.
Antibodies attack the body in everyone. The body has a large number of fail-safe mechanisms to try to prevent the immune system from attacking the body. There are cells that exist to recognise autoimmune antibodies, and make sure that these autoantibodies are shutdown or killed. However in autoimmune diseases the fail-safes fail and so the production of autoantibodies is allowed to continue. So the immune system is simulated in a way that results in it attacking the body, it is unable to shut down autoantibodies, and will not cease their production. When enough damage results you have what is called an autoimmune disease.
Autoimmune reactions can result from chronic stress, leaky gut, infection or some kind of toxic exposure because they stimulate the immune system.
The Gut-Hormone Connection Stealing your Energy:
There is a direct correlation between how exhausted the adrenal glands are and how damaged the gut lining has become.
When you are first having adrenal fatigue, and increased cortisol levels, it can take a few years of stress before GI symptoms result. It is practically a prerequisite to have a gut problem if you have notable adrenal gland burnout. It is also the case that notable gut problems are usually accompanied by some level adrenal fatigue. They cannot be separated.
Cortisol is in charge of the secretion of immunoglobulin A (SIgA). Immunoglobulins protect the intestinal lining against potential foods that could be reactive or cause a problem. It also protects you against potential pathogens like bacteria and parasites or yeast. So, if your adrenals are burned out they cannot produce enough cortisol and your SIgA drops. This is why there is a direct relationship between how stressed you are and your gut health.
If you’re doing something to inflame your gut, you drive cortisol up, because cortisol is an anti-inflammatory hormone. So damage to the gut makes the adrenals worse and damage to the adrenals makes the gut worse. NSAIDs, substances like alcohol and poor dietary decisions cause gut inflammation.
Physical stress can be equally as damaging as emotional stress. So, both physical stress and emotional stress do the same thing, they drive cortisol up and cause gut immunity to drop.
There is a process by which cortisol becomes high, and then later becomes low. Initially we react to stress in such a way that our cortisol levels go up. However if this goes on too long our cortisol levels drop. This process exemplifies the stages of adrenal fatigue.
In stage 1 of adrenal fatigue cortisol levels are high. In stage 2 cortisol levels start to drop. And finally, in stage 3 cortisol levels become very low. The lower the cortisol the more fatigued the adrenals are, and therefore the harder the problem is to fix. An individual with more adrenal fatigue will have more gut issues and their situation will be harder to fix.
Low cortisol also relates to the accumulation of body fat, fatigue, and low sex drive.
How Leaky Gut is Probably Causing All Your Skin Problems
You might have dysbiosis, SIBO, parasites, fungal overgrowth, intestinal permeability, or just a lack of beneficial bacteria. All of these things can directly and indirectly contribute towards a plethora of skin problems. Changes in the gut flora can be due to antibiotic use, not being breast-fed, being born via Caesarean section, eating a poor diet, chronic stress, sleep deprivation, exposure to environmental toxins, et cetera. Changes in gut fora then predispose people to intestinal permeability and inflammation, which as mentioned leads to an inflammatory skin response.
Substance P is a neuropeptide that is produced in the gut, the brain and the skin. Altered gut microbiom promotes the release of substance P in both the gut and the skin. Probiotics have been shown to attenuate or mitigate the situation regarding gut flora.
The gut microbiome also influence lipids and tissue fatty acid profiles, which in turn influence sebum production (an oily waxy substance produced by the sebaceous glands in the skin) and the fatty acid composition of the sebum itself. This can predispose individuals to acne.
There are have a myriad of studies that have noted a significant connection between gut and skin issues.
Two researchers Stokes and Pillsberry were talking about the gut skin axis, as far back as the early 1900s. They said that there is an important link between emotion and skin issues such as acne outbreaks, erythema, urticaria and dermatitis via the physiology and bacteriology of the gut. They noted research at the time that indicated that 40% of acne prone individuals in a given sample had low stomach acid. Low stomach acid can contribute towards SIBO and intestinal permeability. Low stomach acid can therefore contribute to the development of skin issues.
Stokes and Pillsberry suggested a number of remedies including probiotics and cod liver oil (a rich source of EPA and DHEA). EPA and DHEA are both anti-inflammatory. Additionally cod liver oil is a rich source of vitamin A (preformed vitamin A- retinol).
How Gut Inflammation Triggers Depression
There are systemic effects to anti-depressants and psychotropic medicines. In 2009 there were about 235 billion prescriptions written for anti-depressants. The effects of anti-depressants and psychotropic medicines are not completely understood in all cases. That said, they can be very helpful. They are not magic pills. In fact in some cases they may not be the right instrument compared to modulating the immune system and modulating pathology via managing diet, managing gut microbiome, and making sleep changes. Lifestyle changes are more in line with our very complicated pathophysiology than the usage of psychiatric medications.
Inflammatory cytokine model of depression: inflammatory cytokines could be crossing the blood/brain barrier suppressing activity in the frontal cortex which may lead to depression.
If the microbiome is off in your gut it will cause an inflammatory reaction. The immune system near the gut will release sorts of inflammatory cytokines including interleukin 1 (IL 1) and interleukin 6 (IL 6). They send a direct message to the hypothalamus, which in turn tells the pituitary gland to the signal the adrenal glands to release more cortisol. It follows that gut issues can lead to depression, or manifest as the straw that breaks the camel’s back.
How important is it for people to address the gut during the treatment of anxiety and depression?
Switching from a diet of highly processed food to a diet of less processed food will help the gut. Managing sleep is going to help the gut. All these things can affect the gut bacteria and the stress response.
In Victorian times they used to treat TB, depression and anxiety by visiting the seashore wherein they stay out in the sunshine and eat fish. Additionally individuals were taken to countryside mental institutions where they would be taken out in the early morning into the sunshine. When individuals were manic they would lock them in a dark room. Mania is characterised by immense energy, but also psychotic delusions. It happens in various disorders including bipolar and schizophrenia.
You can temporarily sleep deprive a depressed individual for half a night. Their depression will get immediately better, but once they sleep normally it will return as it was before.
Chronic sleep deprivation is a stressor that can cause depression. We are having around 20 less hours of sleep a week relative to 60-70 years ago.
Interestingly a 10,000 lux light box used before 10am in the morning from September to March can be as effective as an antidepressant. This is known as chronotherapy. However it is risky to use the light box after 10am, especially if you have a family history of bipolar.
If you have depression is it prudent to get up at 6:00am or 7:00am and go outside for some morning sun exposure. It is also a good idea to avoid night computer use. If you use your computer at night use blue blockers install Flux on your computer for use after sunset. This will help reset your circadian rhythm.
The blue light sends a signal to the hypothalamus saying “goodmorning”.